Metatarsalgia is a painful condition affecting the metatarsus, which consists of the metatarsal bones of the foot and can be exposed to overloading and high mechanical stresses, especially during sporting and some work activities. The nerves become trapped and cause inflammation, as in the case of Morton’s neuroma. The presence of calluses on the ball of the foot is also common in patients with metatarsalgia. The use of inappropriate footwear, neurological or osteoarticular factors, diseases such as gout or rheumatoid arthritis and biomechanical, or even morphological, considerations, such as pes cavus, Greek or square foot, can contribute to the onset of metatarsalgia.